KMID : 0191120110260070870
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Journal of Korean Medical Science 2011 Volume.26 No. 7 p.870 ~ p.874
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FC¥åRI Gene Promoter Polymorphisms and Total IgE Levels in Susceptibility to Atopic Dermatitis in Korea
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Park Kui-Young
Park Mi-Kyung Kim Eun-Joo Lee Mi-Kyung Seo Seong-Jun
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Abstract
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IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc¥åRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We sought to determine Fc¥åRI gene polymorphisms are associated with AD in Korean patients, and analyzed the relevance of Fc¥åRI gene polymorphisms and serum IgE levels. We conducted a case-control association analysis (175 patients and 56 controls) of Korean subjects. Genotyping was performed using the TaqMan fluorogenic 5¡¯ nuclease assay, and serum levels of IgE were measured using a fluorescence enzyme immunoassay. We found that there were no significant relationships between Fc¥åRI and AD, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels in the Korean AD patients. In conclusion, while the 66T>C (rs2251746) of the Fc¥åRI¥á polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the Fc¥åRI¥â gene did not confer susceptibility to AD in our patient sample.
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KEYWORD
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Atopic dermatitis, Fc¥åRI¥á Polymorphism, Fc¥åRI¥â Polymorphism, Immunoglobulin E
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